Impact of hormone receptor status and tumor subtypes of breast cancer in young BRCA carriers

L Arecco; M Bruzzone; R Bas; HJ Kim; A Di Meglio; R Bernstein-Molho; FS Hilbers; K Pogoda; E Carrasco; K Punie; J Bajpai; E Agostinetto; N Lopetegui-Lia; AH Partridge; KA Phillips; A Toss; C Rousset-Jablonski; G Curigliano; T Renaud; A Ferrari; S Paluch-Shimon; R Fruscio; W Cui; SM Wong; C Vernieri; FJ Couch; MV Dieci; A Matikas; M Rozenblit; D Aguilar-y Méndez; L De Marchis; F Puglisi; A Fabi; SL Graff; I Witzel; A Rodriguez Hernandez; A Fontana; R Pesce; R Duchnowska; HL Pais; V Sini; E Sokolović; E de Azambuja; M Ceppi; E Blondeaux; M Lambertini

Journal article

Impact of hormone receptor status and tumor subtypes of breast cancer in young BRCA carriers

L Arecco, M Bruzzone, R Bas, HJ Kim, A Di Meglio, R Bernstein-Molho, FS Hilbers, K Pogoda, E Carrasco, K Punie, J Bajpai, E Agostinetto, N Lopetegui-Lia, AH Partridge, KA Phillips, A Toss, C Rousset-Jablonski, G Curigliano, T Renaud, A Ferrari Show all

Annals of Oncology | ELSEVIER | Published : 2024

DOI: 10.1016/j.annonc.2024.06.009

Abstract

Background: Hormone receptor expression is a known positive prognostic and predictive factor in breast cancer; however, limited evidence exists on its prognostic impact on prognosis of young patients harboring a pathogenic variant (PV) in the BRCA1 and/or BRCA2 genes. Patients and methods: This international, multicenter, retrospective cohort study included young patients (aged ≤40 years) diagnosed with invasive breast cancer and harboring germline PVs in BRCA genes. We investigated the impact of hormone receptor status on clinical behavior and outcomes of breast cancer. Outcomes of interest [disease-free survival (DFS), breast cancer-specific survival (BCSS), and overall survival (OS)] were..

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